PT-141 (Bremelanotide)
$ 55
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II with a molecular weight of approximately 1,025.2 Da and selective agonist activity at the MC3R and MC4R melanocortin receptor subtypes expressed in the hypothalamus, limbic system, and brainstem — acting through a CNS-direct mechanism independent of peripheral nitric oxide pathways.
Originally developed for studying central melanocortin receptor pathways, PT-141 has been studied extensively for its ability to modulate hypothalamic circuit activity, dopaminergic neurotransmission in the mesolimbic pathway, and CNS-mediated autonomic regulation — with research demonstrating its effects on MC3R/MC4R-mediated downstream signaling, dopamine release in the nucleus accumbens, and hypothalamic regulation of autonomic physiological responses in preclinical models.
Research has focused on PT-141’s role in hypothalamic melanocortin circuit modulation, autonomic nervous system regulation, and dopaminergic pathway interactions — with its CNS-direct mechanism and defined receptor selectivity profile making it a valuable pharmacological tool for studying MC3R/MC4R-mediated signaling alongside compounds such as Semax and Selank. For further reading see: Melanocortin receptor pathway research (PubMed).
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.182 g/mol
PubChem CID: 9941379
CAS Number: 189691-06-3
COA / HPLC / MS
COA / HPLC / MS
3RD PARTY TESTING
3RD PARTY TESTING
Storage
Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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