Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), developed as part of a melanocortin receptor research program at the University of Arizona beginning in the 1980s. The compound is structurally characterized by a cyclic lactam bridge and demonstrates binding affinity to MC-1R, MC-3R, MC-4R, and MC-5R receptor subtypes within the melanocortin receptor family.
Published literature referencing Melanotan II includes investigations into melanocortin receptor subtype pharmacology, ligand-receptor binding kinetics, structure-activity relationships within cyclic α-MSH analogs, and in vitro receptor activation assays. The compound is referenced in biochemical research examining receptor selectivity differences between melanocortin family analogs.
Melanotan 2 Peptide Structure
Peptide Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.198 g/mol
PubChem CID: 92432
CAS Number: 121062-08-6
Source: PubChem
Storage
Storage Instructions:
Store the lyophilized reference standard at minus 20 degrees Celsius, protected from light and moisture. Once placed in solution with a laboratory solvent, hold the solution at 2 to 8 degrees Celsius and use it within 30 days. Solvent selection and handling are the responsibility of the receiving laboratory.
