Follistatin 344 1mg
$ 125
What Is Follistatin 344?
Follistatin (FST) 344 is a synthetic version of the naturally occurring human follistatin protein. Follistatin is found in nearly all tissues of higher animals and comes in two separate isoforms as a result of alternative gene splicing. Its primary biological function is neutralization of proteins in the TGF-beta superfamily. It has particularly potent neutralizing effects on activin, myostatin, and follicle-stimulating hormone.
Source: NCBI Gene
Follistatin 344 Structure
Source: Uniprot
Sequence: MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW
Molecular Weight: 3780 g/mol
PubChem CID: 178101631
Synonyms: Activin-Binding Protein, FSH-Suppressing Protein, FST
Follistatin 344 Effects
Follistatin 344 (FS-344) is a 344-amino acid isoform of the endogenous glycoprotein follistatin with a molecular weight of approximately 37 kDa, characterized by its high-affinity binding and neutralization of activin, myostatin (GDF-8), and other members of the TGF-β superfamily — acting as a potent endogenous antagonist of these ligands by forming non-signaling complexes that prevent receptor binding and downstream SMAD2/3 signaling pathway activation in target tissues.
The FS-344 isoform is distinguished by its heparin-binding domain, which mediates cell surface and extracellular matrix association in target tissues — with research demonstrating that this tissue-binding profile concentrates its antagonist activity locally at sites of expression, making it a particularly useful research tool for investigating tissue-specific roles of activin and myostatin signaling in skeletal muscle biology, reproductive axis regulation, and bone metabolism in preclinical models.
Research has focused on Follistatin 344’s role as a myostatin and activin antagonist in skeletal muscle hypertrophy models, its regulatory function in the hypothalamic-pituitary-gonadal axis through FSH suppression, and its broader role in TGF-β superfamily signaling biology — with its mechanism complementing IGF-1 LR3 & MOTS-C.
For further reading see: Follistatin myostatin antagonism and muscle biology research (PubMed).
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
COA / HPLC / MS
COA / HPLC / MS
3RD PARTY TESTING
3RD PARTY TESTING
Storage
Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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